英文名字 FGF-21, murine recombinant
中文名称 【FGF 21】重组鼠源成纤维细胞生长因子-21(1 mg)
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产品型号
PRP100415
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供应商 BioVision
产品货号 4067-1000
产品报价 ¥106920/1 mg
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产品新闻
背景资料 The FGFs are a family of more than 20 small (~17 26 kDa) secreted peptides. The initial characterization of these proteins focused on their ability to stimulate fibroblast proliferation. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity and, except for FGFR-4, multiple splice isoforms, and FGFR-5, which lacks an intracellular kinase domain. There is growing evidence that FGFRs can be important for regulation of glucose and lipid homeostasis. FGFR-2 appears to be a key molecule during pancreatic development and FGFR-4 has been implicated in cholesterol metabolism and bile acid synthesis. FGF-21 is preferentially expressed in liver, but an exact knowledge of FGF-21 bioactivity and its mode of action have been lacking to date. FGF-21 is a potent activator of glucose uptake on adipocytes, protects animals from diet-induced obesity when overexpressed in transgenic mice, and lowers blood glucose and triglyceride levels when therapeutically administered to diabetic rodents. Fibroblast Growth Factor-21 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 183 amino acids including N-terminal Methionine and having a molecular mass of 20.1 kDa. The amino acid sequence of the recombinant mouse FGF21 is 100% homologous to the amino acid sequence of the mouse FGF21 without signal sequence.
The FGF-21 is purified by proprietary chromatographic techniques.
序列 重组鼠源成纤维细胞生长因子-21蛋白产品,又称FGF21, Fibroblast growth factor 21, FGFL, UNQ3115/PRO10196 .其对应NCBI基因号为56636,对应Accession号为Q9JJN1.
来源宿主 提供的【FGF 21】重组鼠源成纤维细胞生长因子-21产品的来源为大肠杆菌重组表达.
溶解建议 重组鼠源成纤维细胞生长因子-21产品请按照说明书建议进行溶解操作:Centrifuge the vial prior to opening. Reconstitute in sterile H ? to a concentration ≥ 100 ug/ml. This solution can then be diluted into other aqueous buffers. .
保存建议 在您收到艾美捷发出的【FGF 21】重组鼠源成纤维细胞生长因子-21产品后,建议将其置于-20°C保存.
产品说明书
其他 BioVision的公司总部在美丽的旧金山湾地区,它是全球生命科学公司的领导者.BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品,以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为BioVision中国区域总代理,艾美捷与BioVision一道为研究者们提供最好、最新细胞生物学研究工具而不断扩大产品及服务质量.

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