Presenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been linked to early onset of Alzheimer’s disease,probably functioning through its associated g-secretase activity for amyloid-B protein processing. Endogenous presenilin mainly exists in a heterodimeric complex formed from the endoproteolytically processed N-terminal (34 kDa) and C-terminal (~20 kDa) fragments.
应用类型
Western blotting (2-4 ug/ml). However, the optimal concentrations should be determined individually. The antibody recognizes Presenilin 1 of human, mouse, and rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide surrounding amino acid 296 of human Presenilin 1