PTEN （phosphatase and tensin homologue deleted on chromosome ten） phosphatase is a tumor suppressor gene implicated in a wide variety of human cancers. PTEN encodes the 403 amino acid polypeptide originally described as a dual-specificity protein phosphatase. The main substrates of PTEN are inositol phospholipids generated by the activation of the phosphoinositide 3 kinase （PI3K）. PTEN is a major negative regulator of the PI3K/Akt signaling pathway.
应用类型
Western blotting （1-2 ug/ml） and immunoprecipitation （10-20 ug/ml）. However， the optimal concentrations should be determined individually.
免疫原
Recombinant human full length PTEN
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的PTEN蛋白 发生免疫反应.
保存建议
提供的PTEN抗体 产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有50%甘油， 1% BSA和0.02%硫柳汞的PBS缓冲液中.请将该PTEN抗体 产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
