SHP-2 (also known as SHPTP2,Syp,PTP1D and PTP2C) is a ubiquitously expressed tyrosine-specific protein phosphatase. It plays an important role in the control of cell growth,differentiation,migration,and death. Activation of SHP-2 and its association with Gab1 is critical for sustained Erk activation downstream of several growth factor receptors and cytokines.
应用类型
Western blotting (0.5-4 ug/ml), immunoprecipitation (10-20 ug/ml) and Immunohistochemistry (20-30 ug/ml). However, the optimal concentrations should be determined individually.
免疫原
Synthetic peptide corresponding to the N-terminus of human SHP-2
来源宿主
兔
反应性
经检测验证,可与人、小鼠、大鼠种属来源的SHP-2蛋白发生免疫反应.
保存建议
提供的SHP-2抗体产品为100 ug 无色溶液,其浓度为0.5 mg/ml,溶解于包含有50%甘油, 1% BSA和0.02%硫柳汞的PBS缓冲液中.请将该SHP-2抗体产品置于-20 ℃冷冻保存,建议分装使用以避免反复冻融.