The TLR （toll-like receptors） family of proteins are characterized by a highly conserved Toll homology （TH） domain，which is essential for Toll-induced signal transduction. TLR1，as well as the other TLR family members，are type I transmembrane receptors that characteristically contain an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride （LPS） stimulation，which results in the activation and translocation of NFκB and suggests that these receptors are involved in mediating inflammatory responses. Expression of TLR receptors is highest in peripheral blood leukocytes，macrophages，and monocytes. TLR6 is highly homologous to TLR1，sharing greater that 65% sequence identity，and，like other members of TLR family，it induces NFκB signaling upon activation.
应用类型
Western blotting （1:200-1000） and ELISA （1:100-500）. However， the optimal concentrations should be determined individually.
免疫原
Recombinant human TLR1
来源宿主
山羊
反应性
经检测验证，可与人种属来源的TLR1蛋白发生免疫反应.
保存建议
提供的TLR1抗体产品为100 ul 无色溶液，其浓度为N/A，溶解于包含有50%甘油， 1% BSA和0.02%硫柳汞的PBS缓冲液中.请将该TLR1抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
