A1 (also designated Bfl-1) is a Bcl-2 family protein that dimerizes with both Bcl-2 and Bax,and has been identified as a hematopoietic-specific,early inducible gene. Although A1 demonstrated properties similar to those of Bcl-2,its function may be more temporally regulated during myeloid differentiation and is dependent on additional growth stimuli to confer its life promoting properties. A1 is abundantly expressed in bone marrow and at low levels in other tissues. A1 expression has been correlated to stomach cancer.
应用类型
Western blotting (0.5-4 ug/ml), immunoprecipitation, and Immunohistochemistry. However, the optimal conditions should be determined individually. The A1 antibody detects A1 (Bfl-1) of human, mouse, and rat origins.
免疫原
Synthetic peptide surrounding amino acid 37 of human A1