Erk-5 shares high homology in the amino-terminal kinase domain with Erk1/2. However,the long carboxy-terminal kinase domain makes Erk5 a unique MAP kinase. Erk5 is activated by a variety of extracellular signals. The direct upstream kinase of Erk5 is defined as MEK5. Studies show that Erk5 pathway is involved in proliferation,differentiation,oncogenesis,and development.
应用类型
Western blotting (0.5-4 ug/ml). However, the optimal concentrations should be determined individually. The antibody recognizes ~115 kDa Erk5 of human, mouse, and rat origins.
免疫原
Synthetic peptide from human Erk5
来源宿主
兔
反应性
经检测验证,可与人、小鼠、大鼠种属来源的Erk5蛋白 发生免疫反应.
保存建议
提供的Erk5抗体 产品为100 ug 无色溶液,其浓度为0.5 mg/ml,溶解于包含有50%甘油, 1% BSA和0.02%硫柳汞的PBS缓冲液中.请将该Erk5抗体 产品置于-20 ℃冷冻保存,建议分装使用以避免反复冻融.