Members of TRAF family associate with activated TNF-R and CD40 and have been implicated to induce nuclear translocation of NFkB. TANK can bind to all three TRAFs and synergizing with TRAF2 to activate the NFkB signal cascade.
应用类型
Western blotting (0.5-4 ug/ml) and in immunoprecipitation (10-20 ug/ml), and Immunohistochemistry (10-20 ug/ml). However, the optimal conditions should be determined individually. Mouse small intestine tissue lysate can be used as a positive control.
免疫原
Synthetic peptide surrounding amino acid 413 of human TANK