ILP-2 (for IAP-like protein-2) is a novel member of in the IAP (Inhibitor of Apoptosis) protein family. ILP-2 has high homology to ILP-1,but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. ILP-2,unlike ILP-1,has no inhibitory effect on Fas and TNF induced apoptosis,but potently inhibit apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9.
应用类型
Western blotting (0.5-4 ug/ml). However, the optimal dilution conditions should be determined individually. The affinity-purified rabbit antibody recognizes ~32 kDa ILP-2 in samples from human, mouse and rat origins.
免疫原
Synthetic peptide surrounding amino acid 23 of human ILP-2