Caspase-6 is one of the major executioner caspases functioning in cellular apoptotic processes. Similar as other caspases,caspase-6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Caspase-6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.
应用类型
Western blotting (0.5-4 ug/ml). However, the optimal conditions should be determined individually. Jurkat cell lysate (Cat.# 2401-100), mouse intestine (Cat.# 2601-100), and rat kidney (Cat. 2702-100) tissue lysate can be used as a positive controls. The antibody detects a full length (35 kDa) and the cleaved fragment (18 kDa) of caspase-6.
免疫原
Synthetic peptide mapping to the C-terminus of rat caspase-6 large fragment