Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors，TNF-R1 and Fas. Several novel death receptors including DR3，DR4，DR5，and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domain. SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex，which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.
应用类型
Western blot analysis （1-2 ug/ml）. However， the optimal conditions should be determined individually. The antibody detects an approximately 60 kDa human SODD by Western blot analysis. HeLa and THP-1 cell lysate can be used as positive control.
免疫原
Synthetic peptide mapping to the N-terminus of human SODD
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的SODD蛋白发生免疫反应.
保存建议
提供的SODD抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有50%甘油， 1% BSA， 0.02%硫柳汞的PBS （pH 7.2）缓冲液中.请将该SODD抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
