Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors,TNF-R1 and Fas. Several novel death receptor including DR3,DR4,and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor 6. Like TNF-R1,DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed in human tissues and cell lines.
应用类型
Western blotting (0.5-4 ug/ml). However, the optimal conditions should be determined individually. The antibody detects ~68 kDa of DR6 in samples from human, mouse and rat origins.
免疫原
Synthetic peptide surrounding amino acid 622 of rat DR6
来源宿主
兔
反应性
经检测验证,可与人、小鼠、大鼠种属来源的DR6蛋白发生免疫反应.
保存建议
提供的DR6抗体产品为100 ug 无色溶液,其浓度为0.5 mg/ml,溶解于包含有30%甘油和0.01%硫柳汞的PBS (pH 7.2)缓冲液中.请将该DR6抗体产品置于-20 ℃冷冻保存,建议分装使用以避免反复冻融.