CD40，also known as bp50 or CDW40，is a type I membrane protein found on the surface of B cells and primary carcinomas. It belongs to the TNF-R family. CD40 serves as the receptor for CD40 ligand （CD40L），a cytokine expressed on the cell surface of T cells. CD40 plays a critical role in B cell proliferation，antibody class switching，modulation of apoptosis in the germinal center through interaction with T cells expressing CD40L，and activation of CD4+ T cells. Ligation of CD40 with its ligand preferentially induces stress-activated protein kinases in B lymphocytes.
应用类型
Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Jurkat cell lysate can be used as a positive control.
免疫原
Synthetic peptide surrounding amino acid 246 of human CD40 Ligand
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的CD40L蛋白发生免疫反应.
保存建议
提供的CD40L抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该CD40L抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
