Survivin is a newly described apoptosis inhibitor that is expressed in many human cancers,but undetectable in terminally differentiated adult tissues. It has been shown that recombinant expression of Survivin conteracts apoptosis of B lymphocyte precursors deprived of interleukin 3 (IL-3),suggesting a potential role of Survivin in cancer therapy. Survivin interacts with the processed form of caspase-3 and inhibits its proteolytic activity.
应用类型
Western blot analysis (0.5 - 2 ug/ml). However, the optimal conditions should be determined individually. The immunoaffinity purified antibody detects an approximately 17 kDa mouse survivin by Western blot analysis. Mouse spleen tissue lysate can be used as positive control.
免疫原
Synthetic peptide surrounding amino acids near the C-terminus of mouse survivin