Survivin is a newly described apoptosis inhibitor that is expressed in many human cancers,but undetectable in terminally differentiated adult tissues. It has been shown that recombinant expression of Survivin counteracts apoptosis of B lymphocyte precursors deprived of interleukin 3 (IL-3),suggesting a potential role of Survivin in cancer therapy. Survivin is expressed in G2-M phase in a cell cycle-dependent manner and directly associated with mitotic spindle microtubules,suggesting a role in both apoptosis regulation and cell cycle progression.
应用类型
Western blot analysis (0.5-4 ug/ml). However, the optimal conditions should be determined individually.
免疫原
Synthetic peptide surrounding amino acids near the C-terminus of human survivin
来源宿主
兔
反应性
经检测验证,可与人种属来源的Survivin蛋白发生免疫反应.
保存建议
提供的Survivin抗体产品为100 ug 无色溶液,其浓度为0.2 mg/ml,溶解于包含有30%甘油, 0.5% BSA, 0.01%硫柳汞的PBS (pH 7.2)缓冲液中.请将该Survivin抗体产品置于-20 ℃冷冻保存,建议分装使用以避免反复冻融.