Protein kinases are enzymes that transfer a phosphate group from a phosphate donor,generally the g phosphate of ATP,onto an acceptor amino acid in a substrate protein. By this basic mechanism,protein kinases mediate most of the signal transduction in eukaryotic cells,regulating cellular metabolism,transcription,cell cycle progression,cytoskeletal rearrangement and cell movement,apoptosis,and differentiation. With more than 500 gene products,the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
应用类型
The antibody can be used for ELISA (0.25 ug/ml) and Immunohistochemistry (2.5 – 5.0 ug/ml).
免疫原
Synthetic peptide selected from the N-terminal region of human PI3KB
来源宿主
兔
反应性
经检测验证,可与人种属来源的PI3KB蛋白发生免疫反应.
保存建议
提供的PI3KB抗体产品为100 ug 无色溶液,其浓度为0.25 mg/ml,溶解于包含有0.09% (W/V) 叠氮钠的PBS缓冲液中.请将该PI3KB抗体产品置于-20 ℃冷冻保存,建议分装使用以避免反复冻融.