DR5 is the DD containing receptor for TRAIL,Apo2,TRAIL-R2,TRICK2,or KILLER. DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. Like DR3 and TNFR1,DR5 mediate apoptosis by FADD dependent pathway. Over-expression of DR5 induces apoptosis and activates NFkB.
应用类型
Western blot analysis (0.5-4 ug/ml). However, the optimal conditions should be determined individually. The antibody detects 60 kDa DR5 in samples of human and mouse origins
免疫原
Synthetic peptide corresponding to residues surrounding amino acid 372 of mouse DR5 precursor
来源宿主
兔
反应性
经检测验证,可与人、小鼠种属来源的DR5蛋白发生免疫反应.
保存建议
提供的DR5抗体产品为100 ug 无色溶液,其浓度为0.2 mg/ml,溶解于包含有30%甘油, 0.5% BSA, 0.01%硫柳汞的PBS (pH 7.2)缓冲液中.请将该DR5抗体产品置于-20 ℃冷冻保存,建议分装使用以避免反复冻融.