PBR (Peripheral-type Benzodiazepine Receptor) is a ubiquitous protein (18 kDa) found in most steroidogenic tissues. It is located primarily in the outer mitochondrial membrane of steroid-producing tissues and is found in association with a 34 kDa voltage-dependent anion channel protein (VDAC). PBR is involved in the regulation of cholesterol transport from the outer to the inner mitochondrial membrane. It is thought to be part of the mitochondrial permeability transition pore (PT) and to be involved in apoptosis.
应用类型
Western blot analysis (0.5-4 ug/ml) and Immunohistochemistry (10-20 ug/ml). However, the optimal conditions should be determined individually.
免疫原
Synthetic peptide surrounding amino acid 81 of mouse PBR
来源宿主
兔
反应性
经检测验证,可与人、小鼠、大鼠种属来源的PBR蛋白发生免疫反应.
保存建议
提供的PBR抗体产品为100 ug 无色溶液,其浓度为0.2 mg/ml,溶解于的PBS (pH 7.2)缓冲液中.请将该PBR抗体产品置于-20 ℃冷冻保存,建议分装使用以避免反复冻融.