Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-1 （ICE，interleukin-1B-converting enzyme） is the mammalian caspase responsible for the proteolytic conversion of the proforms of interleukin-1B and IL-18 into active cytokines. Like other caspases，Caspase-1 itself is synthesized as a pro-enzyme that is cleaved during activation into a large （20 kDa） and small （10 kDa） subunits. The cellular role of caspase-1 appears limited to cytokine activation as they do not have obvious roles in apoptosis.
应用类型
Western blot analysis （0.5-4 ug/ml）， immunoprecipitation （4-8 ug/ml） and immunofluorescence （10-20 ug/ml）. The immunoaffinity purified antibody recognizes 45 kDa procaspase-1 and the 20 kDa cleaved product.
免疫原
Synthetic peptide surrounding amino acid 132 of human caspase-1
