7-alpha, 25-dihydroxycholesterol (EBI2 agonist, EBI2 Activator, GPR183 Activator, 7alpha,25-OHC)-7-alpha, 25-dihydroxycholesterol (EBI2 agonist, EBI2 Activator, GPR183 Activator, 7alpha,25-OHC)-生化试剂-艾美捷科技有限公司

PRODUCT CENTER

生化试剂

产品中心

当前位置：首页 > 产品中心 > 分子生化产品 > 生化试剂

中文名称: 7-alpha, 25-dihydroxycholesterol (EBI2 agonist, EBI2 Activator, GPR183 Activator, 7alpha,25-OHC)

英文名字: 7-alpha, 25-dihydroxycholesterol (EBI2 agonist, EBI2 Activator, GPR183 Activator, 7alpha,25-OHC)

背景资料: USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！

产品描述: A highly potent and specific oxysterol EBI2 (GPR183) agonist with a kd of 450pM in a saturation binding analysis, and activates EBI2 (EC50=140pM compared with 2.1nM for its enantiomer 7b,25-OHC) in a GTP-gamma assay. Dose-dependenty suppresses forskolin-induced cAMP accumulation in EBI2-expressing SK-N-MC/CRE-beta galactosidase cell line with an IC50 of 2nM, but not in control cells. Stimulates migration of LPS-activated spleen B cells and T cells in a dose-dependent manner. In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells from EBI2-deficient mice.Formula:C27H46O3Solubility:DMSOMolar Mass:418.3Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

保存建议: 接收到7-alpha, 25-dihydroxycholesterol (EBI2 agonist, EBI2 Activator, GPR183 Activator, 7alpha,25-OHC)产品后，置于-20°C温度下保存。

其他: Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。