中文名称

Prealbumin, Human, Positive Control for Western Blot (Transeryhtin, TTR)

英文名字

Prealbumin, Human, Positive Control for Western Blot (Transeryhtin, TTR)

供应商

USBiological

产品货号

209151

产品报价

￥1/100ul

产品说明书

点击查看

购买方式

银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868

产品新闻

背景资料

USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！

产品描述

Transthyretin (TTR) is a serum and cerebrospinal fluid carrier of the thyroid hormone thyroxine (T4) and retinol binding protein bound to retinol. This is how transthyretin gained its name, transports thyroxine and retinol. The liver secretes transthyretin into the blood, and the choroid plexus secretes TTR into the cerebrospinal fluid. TTR was originally called prealbumin[1] because it ran faster than albumin on electrophoresis gels. It functions in concert with two other thyroid hormone-binding proteins (Albumin and TBG) in the serum. In cerebrospinal fluid TTR is the primary carrier of T4, as albumin is not present. TTR also acts as a carrier of retinol (vitamin A) through its association with retinol-binding protein (RBP) in the blood and the CSF. Less than 1% of TTR's T4 binding sites are occupied in blood, which is taken advantage of below to prevent TTRs dissociation, misfolding and aggregation which leads to the degeneration of post-mitotic tissue.TTR is a 55kD homotetramer with a dimer of dimers configuration that is synthesized in the liver, choroid plexus and retinal pigment epithelium for secretion into the eye. Each monomer is a 127- residue polypeptide rich in beta sheet structure. Association of two monomers forms an extended beta sandwich. Further association of two of these dimers produces the homotetrameric structure and creates the two thyroxine binding sites per tetramer. This dimer- dimer interface comprising the two T4 binding sites is the weaker dimer-dimer interface and is the one the comes apart first in the process of tetramer dissociation. TTR is known to be associated with the amyloid diseases[9] senile systemic amyloidosis (SSA),[10] familial amyloid polyneuropathy (FAP),[11][12] and familial amyloid cardiomyopathy (FAC). It is found in serum/plasma at ~0.30 mg/ml. Functions in the transport of thyroxine, vitamin A, and retinol-binding protein. Clinically, prealbumin is a sensitive indicator of impaired liver function; low levels are found in viral hepatitis, cirrhosis, malnutrition, inflammation, and surgical trauma.Applications: Suitable for use as Positive Control for Western Blot. Not suitable for ELISA or other applications where native protein is required. Other applications not tested.Recommended Dilution:Optimal dilutions to be determined by the researcher.Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

产品形式

Supplied in SDS-PAGE sample buffer (reduced)。Add 5ul of fresh 2x sample buffer/10ul of the solution prior to heating and loading on gels。

保存建议

接收到Prealbumin, Human, Positive Control for Western Blot (Transeryhtin, TTR)产品后，置于-20°C温度下保存。

其他

Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

分享到：