中文名称

Fetuin, Human (Fetuin A, AHSG, Alpha 2-HS Glycoprotein)

英文名字

Fetuin, Human (Fetuin A, AHSG, Alpha 2-HS Glycoprotein)

供应商

USBiological

产品货号

208895

产品报价

￥1/1mg

产品说明书

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购买方式

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产品新闻

背景资料

USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！

产品描述

The product of the AHSG gene is commonly referred to as fetuin in species other than the human. The first fetal plasma protein to be described was fetuin, which was purified from fetal and newborn calf serum by Pedersen in 1944. Fetuin was subsequently shown to be a very abundant plasma protein in fetal cattle, sheep, pig, and goat, and also to be present in humans and rodents. Fetuins are proteins, which are made in the liver and secreted into the blood. They belong to a large group of binding proteins mediating the transport and availability of a wide variety of substances (drugs, hormones, fatty acids, vitamins etc) in the blood. The best known representative of these carrier proteins is serum albumin, the most abundant protein in the blood plasma of adult animals. Fetuin is more abundant in fetal blood, hence the name fetuin (from lat. fetus). Fetal calf serum contains more fetuin than albumin, while adult serum contains more albumin than fetuin.Human fetuin is synonymous with 2-HS-Glycoprotein (genetic symbol AHSG), a2-HS, A2HS, AHS, HSGA and fetuin-A. Fetuin-A exists as a single copy gene in the human and mouse genomes. A closely related gene, fetuin-B also exists in the human, rat and mouse genomes. Like fetuin-A fetuin-B is made predominantly by the liver and to a lesser extent by a number of secretory tissues. Fetuins exist it in all vertebrate genomes including fish and reptiles. Thus fetuins belong to the cystatin superfamily of proteins. Fetuin relatives within this superfamiliy are the histidine- rich glycoprotein (HRG) and kininogen (KNG). Fetuin-A deficiency dramatically increased the calcification proneness of these mice in that all mice sponteneously calcified throughout their body even without mineral-rich diet or surgical tissue trauma. Therefore Fetuin A is regarded as a potent inhibitor of systemic calcification. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation.Fetuin is a mixture of proteins containing a wider range of growth factors and attachments factors normally found in fetal calf serum. The major protein in fetuin is ~48.5Kd (74% protein; glycosylated). The other minor components of fetuins are alpha-1 and alpha-2 globulins and variety of growth factors such as IGF- 1/2 and FGFs. Fetuins, along with Transferrin, selenium and insulin, have been used in serum-free defined media formulations to increase cell attachment and growth. Fetuin is also an effective serine protease and it may improve cellular viability by inhibiting several proteases.Source:Fetuin, from human seraMolecular Weight:~49kDStorage and Stability:Lyophilized powder may be stored at -20°C. Reconstitute with sterile sterile saline or culture medium. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

产品形式

该产品为冻干粉 in 20mM Tris-HCl, pH 8.0, 200mM sodium chloride，缓冲液为：sterile saline or culture medium。

保存建议

接收到Fetuin, Human (Fetuin A, AHSG, Alpha 2-HS Glycoprotein)产品后，置于-20°C温度下保存。

其他

Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。

注意

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