GANT58(25毫克)产品是Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC₅₀ ~ 5 uM in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo.