Noscapine is an opioid alkaloid with antitussive and antimitotic properties.{28232} It binds to tubulin and arrests mammalian cells in mitosis at a concentration of 20 ?M.{28233} Noscapine induces apoptosis (IC50 = 25 and 10 ?M in HeLa cells and thymocytes, respectively) and demonstrates antitumor activity both in vitro (IC50 = 42.3 and 39.1 ?M in MCF-7 and Renal 1983 cell lines, respectively) and in mice.{28233}
产品描述
An opioid alkaloid that binds to tubulin and arrests mammalian cells in mitosis at a concentration of 20 ?M; induces apoptosis (IC50 = 25 and 10 ?M in HeLa cells and thymocytes, respectively) and demonstrates antitumor activity both in vitro (IC50 = 42.3 and 39.1 ?M) and in mice
