Emtricitabine is a cytidine analog with an unnatural β-L structural configuration that inhibits reverse transcriptase, preventing replication of HIV-1 (EC50 = 10-20 nM) and hepatitis B (EC50 = 10-40 nM).{27859,27860} It is activated through multistep intracellular phosphorylation by various cellular kinases.{27859} Emtricitabine, when used alone or in combination therapies, has been shown to reduce viral load and to induce immunological clearance via T cells.{27861}
产品描述
A cytidine analog with an unnatural β-L structural configuration that inhibits reverse transcriptase, preventing replication of HIV-1 (EC50 = 10-20 nM) and hepatitis B (EC50 = 10-40 nM)