中文名称

SB 1518; 11- [2-（1-吡咯烷基）乙氧基] -14,19-二恶英-5,7,27-三氮杂四环[19.3.1.12,6.18,12] heptacosa-1（25），2,4,6（27） ，8,10,12（26），16E，21,23-十碳烯

英文名字

SB 1518; 11-[2-(1-pyrrolidinyl)ethoxy]-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16E,21,23-decaene

供应商

Cayman Chemical

产品货号

16709-1

产品报价

￥询价/1mg

产品说明书

点击查看

购买方式

银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868

产品新闻

背景资料

FMS-like tyrosine kinase 3 (FLT3) and Janus kinase 2 (JAK2) are tyrosine kinases that mediate cytokine signaling and are frequently mutated in cancers, particularly acute myeloid leukemia.{27422,27424} Pacritinib is an inhibitor of both FLT3 and JAK2 (IC50s = 22 and 23 nM, respectively).{27422} It also blocks the activities of the FLT3 D835Y mutant, FLT3 with internal tandem duplications (ITDs), and JAK2 with a V617F substitution (IC50s = 6, 20-180, and 220 nM, respectively).{27422} Pacritinib also inhibits JAK1, JAK3, and TYK2 (IC50s = 1280, 520, and 50 nM, respectively).{27422} Pacritinib is orally bioavailable, inhibiting FLT3 and JAK2 signaling, tumor growth, and metastasis in xenografts in mice.{27422} It is synergistic with the histone deacetylase inhibitor pracinostat (also known as SB 939, Item No. 10443), decreasing cell proliferation and inducing apoptosis in cells carrying either the JAK2 V617F mutation or FLT3 with ITDs, both in vitro and in vivo.{27423} Pacritinib has potential in resolving hematological malignancies.{27424}

产品描述

An inhibitor of both FLT3 and JAK2 (IC50s = 22 and 23 nM, respectively); blocks the activities of the FLT3 D835Y mutant, FLT3 with ITDs, and JAK2 with a V617F substitution (IC50s = 6, 20-180, and 220 nM, respectively); orally bioavailable, inhibiting tumor growth and metastasis in xenografts in mice

产品形式

A crystalline solid

保存建议

建议您在收到Cayman Chemical品牌的Pacritinib​ (1 mg)产品后置于-20度保存，产品有效期为730天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

分享到：