- 中文名称
顺-4-[(4-氯苯基)磺酰基] -4-(2,5-二氟苯基)-环己烷丙酸
- 英文名字
- cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-cyclohexanepropanoic acid
- 供应商
- Cayman Chemical
- 产品货号
- 16706-10
- 产品报价
- ¥询价/10mg
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- γ-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and β-amyloid precursor protein (APP), within the transmembrane domain.{27051,25415} MK 0752 is a potent, reversible inhibitor of γ-secretase, reducing the cleavage of APP to Aβ40 in human neuroblastoma SH-SY5Y cells with an IC50 value of 5 nM.{27408,27409} It is orally bioavailable and crosses the blood-brain barrier, as orally administered MK 0752 dose-dependently reduces the generation of new amyloid β protein in the brain of rhesus monkeys.{27409} Through its effects on the Notch pathway, MK 0752 reduces the number of breast cancer stem cells in tumorgrafts, enhancing the efficacy of the chemotherapy drug docetaxel (Item No. 11637) in mice with breast cancer tumors.{27410}
- 产品描述
- A potent, reversible inhibitor of γ-secretase, reducing the cleavage of APP to Aβ40 in SH-SY5Y cells with an IC50 value of 5 nM; orally bioavailable and crosses the blood-brain barrier, as orally administered MK 0752 dose-dependently reduces the generation of new amyloid β protein in the brain of rhesus monkeys
- 产品形式
- A crystalline solid
- 保存建议
- 建议您在收到Cayman Chemical品牌的MK 0752 (10 mg)产品后置于-20度保存,产品有效期为730天.
- 其他
- Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒,其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒,如:类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等;也提供多种高质量试剂,包括:类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理,艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.
- 注意
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该页面的中文产品信息的翻译,仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前,请浏览说明书确认。
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