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中文名称

PORCN抑制剂II;4-(2-甲基-4-吡啶基)-N- [4-(3-吡啶基)苯基]-苯乙酰胺

英文名字
PORCN Inhibitor II; 4​-​(2​-methyl​-4​-​pyridinyl)​-​N​-​[4​-​(3​-​pyridinyl)​phenyl]​-benzeneacetamide
供应商
Cayman Chemical
产品货号
16644-50
产品报价
¥询价/50mg
产品说明书
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产品新闻
背景资料
Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins.{27064} This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer.{27064,27062} Wnt-C59 is a potent inhibitor of PORCN, as measured by prevention of Wnt3A activation (IC50 = 74 pM).{27062} As palmitoylation of Wnt is required for its secretion, Wnt-C59 completely blocks Wnt3A secretion into culture media.{27062} Wnt-C59 prevents activation of all evaluated Wnt family members.{27062} This compound is effective in vivo as well as in vitro. Whether given by intravenous (2.5 mg/kg) or oral administration (5 mg/kg), Wnt-C59 displays a half-life in blood of approximately 1.94 hours, and remains greater than 10-fold above the in vitro IC50 concentration for at least 16 hours after a single oral dose.{27062} It blocks the progression of both basal-like and triple-negative breast cancers while downregulating Wnt/β-catenin pathway target genes in mice.{27062,27063}
产品描述
A potent inhibitor of PORCN (IC50 = 74 pM), completely blocking Wnt secretion into culture media; prevents activation of all evaluated Wnt family members; effective in vivo as well as in vitro; blocks the progression of breast cancer while downregulating Wnt/β-catenin pathway target genes in mice
产品形式
A crystalline solid
保存建议
建议您在收到Cayman Chemical品牌的Wnt-C59 (50 mg)产品后置于-20度保存,产品有效期为730天.
其他
Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒,其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒,如:类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等;也提供多种高质量试剂,包括:类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理,艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.
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