Progesterone (Item No. 15876) is a steroid secreted by the corpus luteum and placenta. It is responsible for preparing the uterine lining for implantation of a fertilized ovum and to maintain pregnancy. Norgestimate is a synthetic progesterone analog (i.e., a progestin) that acts as a prodrug to norelgestromin, the primary active metabolite, and levonorgestrel (Item No. 10006318).{12452} It is deacetylated in the intestine and liver to form the two active metabolites.{12452} Norgestimate selectively binds the progesterone receptor and is androgenically neutral.{29990,29991} A USP-approved grade of norgestimate is formulated in combination with ethynyl estradiol and provided under the trade name Ortho-Tri-Cyclen™ for use as an oral contraceptive.
产品描述
A synthetic progestin that acts as a prodrug to norelgestromin and levonorgestrel; selectively binds the progesterone receptor and is androgenically neutral