SIRT2抑制剂,AGK2(10毫克)产品是A potent inhibitor of sirtuin 2 (SIRT2) (IC50 = 3.5 uM). AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRt3. Inhibition of SIRT2 rescued α-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson’s disease.