中文名称

ATM / ATR激酶抑制剂；α-苯基N- [2,2,2-三氯-1-[[[（4-氟-3-3-硝基苯基）氨基]硫代甲基]氨基]乙基]-苯乙酰胺

英文名字

ATM/ATR Kinase Inhibitor; α-​phenyl-​N-​[2,​2,​2-​trichloro-​1-​[[[(4-​fluoro-​3-​nitrophenyl)​amino]​thioxomethyl]​amino]​ethyl]​-benzeneacetamide

供应商

Cayman Chemical

产品货号

16242-1

产品报价

￥已停产

产品说明书

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购买方式

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产品新闻

背景资料

Ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) kinases mediate the DNA damage response pathway in cells upon encounter with genotoxic agents. Their signaling can activate cell cycle arrest, DNA repair, induction of premature senescence, and cell death. Inhibiting this pathway is one strategy implemented to increase the therapeutic capacity of certain genotoxic anti-cancer regimens by sensitizing cancer cells to these agents.{27525,26648} CGK733, a thiourea-containing compound, was originally identified as a specific inhibitor of ATR and ATM kinases (IC50 = ~ 200 nM).{27525} In prematurely senescent breast, lung, and colon cancer cells CGK733 reportedly suppresses ATM-mediated p21 expression required for survival, resulting in cell death.{26648} Human cancer cell lines exposed to both caffeine and CGK733 demonstrate a rapid decline in cyclin D1 protein levels and a reduction in retinoblastoma protein levels, which leads to the inhibition of their proliferation.{27525}

产品描述

An inhibitor of ATR and ATM kinases (IC50 = ~ 200 nM) that induces cell death in prematurely senescent breast, lung, and colon cancer cells

产品形式

A crystalline solid

保存建议

建议您在收到Cayman Chemical品牌的CGK733 (1 mg)产品后置于-20度保存，产品有效期为730天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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