Salmeterol xinafoate is a long-acting, selective β2-adrenergic agonist with bronchodilator actions (EC50 = 0.25 µM) that has been used clinically to treat asthma and COPD.{25444,25442,25443} It demonstrates 2,818-fold selectivity for β2-adrenergic receptors over β1-adrenergic receptors.{25151} Salmeterol binds to an exosite domain of β2-adrenergic receptors, producing a slow onset of action and prolonged activation.{25994}
产品描述
A long-acting, selective β2-adrenergic agonist with bronchodilator actions (EC50 = 0.25 µM) that demonstrates 2,818-fold selectivity for β2-adrenergic receptors over β1-adrenergic receptors