中文名称

Claritin | SCH 29851;?4-（8-氯-5,6-二氢-11H-苯并[5,6]环庚[1,2-b]吡啶-11-亚基）-乙酯-1-哌啶羧酸

英文名字

Claritin|SCH 29851; 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-ethyl ester-1-piperidinecarboxylic acid

供应商

开曼生物

产品货号

15625-25

产品报价

￥1/25mg

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产品新闻

背景资料

Loratadine is a non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM).{25629,22788,25628} It has been shown to inhibit the release of leukotriene C4 (IC50 = 8 ?M) and histamine (IC50 = 11 ?M) from rodent mast cells and to inhibit allergic bronchospasm in guinea pigs with an ED50 value of 0.40 mg/kg.{25627}

产品描述

A non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM); inhibits the release of LTC4 (IC50 = 8 ?M) and histamine (IC50 = 11 ?M) from rodent mast cells and inhibits allergic bronchospasm in guinea pigs (ED50 = 0.40 mg/kg)

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