Glutathione can occur in reduced (GSH), oxidized (GSSG), or in mixed disulfide forms and is ubiquitous in multiple biological systems serving as the major thiol-disulfide redox buffer of the cell.{11632} GSSG is the oxidized form of GSH (Item No. 10007461). It can be reduced back to GSH through the NADPH-dependent enzyme glutathione reductase.{11632} GSSG functions as a hydrogen acceptor in the enzymatic determination of NADP+ and NADPH and can be a proximal donor in S-glutathionylation post translational modifications.{25273} The ratio of reduced glutathione to oxidized glutathione within cells is often used as an indicator of oxidative stress, with higher concentrations of GSSG predicting increased oxidative stress.{25274}
产品描述
The oxidized form of GSH that can be reduced back to GSH through the NADPH-dependent enzyme glutathione reductase; functions as a hydrogen acceptor in the enzymatic determination of NADP+ and NADPH and can be a proximal donor in S-glutathionylation post translational modifications