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重组蛋白
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中文名称

重组人染色框同源物3(25ug)

英文名字
CBX3 (human recombinant)
供应商
Cayman Chemical
产品货号
15467-25
产品报价
¥已停产
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产品新闻
背景资料
The heterochromatin protein 1 (HP1) family, which consists of isoforms HP1-α (CBX5), HP1-β (CBX1), and HP1-r (CBX3), are chromatin-associated proteins involved in gene regulation and heterochromatin formation.{20846} CBX proteins have an N-terminal chromodomain, a C-terminal chromoshadow domain, and a hinge domain that connects the two.{23468} Extensive post-translational modifications have been observed and mapped on the CBX proteins.{23471} The chromodomain of CBX3 has been shown to recognize methylated histone H3 lysine 9, methylated histone H1 lysine 26, and G9A methylated at lysine 185.{25450} CBX3 associates with the exons of a subset of actively transcribed genes, and loss of CBX3 results in accumulation of unspliced mRNA from that subset of genes.{25452,25453} Further, CBX3 suppresses Nanog gene transcription in pre-induced pluripotent stem cells and long terminal repeat protein expression in HIV-1 infected cells.{25453,25449} Knockdown of CBX3 by siRNA in cells latently infected with HIV-1 leads to virus reactivation.{25448} CBX3 has been proposed to be a biomarker for tumor stem cells in osteosarcoma.{25451}
产品描述
提供的重组人染色框同源物3(25ug)产品形式为:50 mM Tris, pH 7.4, containing 150 mM sodium chloride and 20% glycerol.
产品形式
The heterochromatin protein 1 (HP1) family, which consists of isoforms HP1- (CBX5), HP1- (CBX1), and HP1-r (CBX3), are chromatin-associated proteins involved in gene regulation and heterochromatin formation.{20846} CBX proteins have an N-terminal chromodomain, a C-terminal chromoshadow domain, and a hinge domain that connects the two.{23468} Extensive post-translational modifications have been observed and mapped on the CBX proteins.{23471} The chromodomain of CBX3 has been shown to recognize methylated histone H3 lysine 9, methylated histone H1 lysine 26, and G9A methylated at lysine 185.{25450} CBX3 associates with the exons of a subset of actively transcribed genes, and loss of CBX3 results in accumulation of unspliced mRNA from that subset of genes.{25452,25453} Further, CBX3 suppresses Nanog gene transcription in pre-induced pluripotent stem cells and long terminal repeat protein expression in HIV-1 infected cells.{25453,25449} Knockdown of CBX3 by siRNA in cells latently infected with HIV-1 leads to virus reactivation.{25448} CBX3 has been proposed to be a biomarker for tumor stem cells in osteosarcoma.{25451}
保存建议
建议您在收到Cayman Chemical品牌的重组人染色框同源物3(25ug)产品后置于-80度保存,产品有效期为180天.
其他
Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒,其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒,如:类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等;也提供多种高质量试剂,包括:类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理,艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.
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