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重组蛋白
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中文名称

重组人HMG-乙酰辅酶A还原酶(250ug)

英文名字
HMG-CoA Reductase (human recombinant)
供应商
Cayman Chemical
产品货号
14944-250
产品报价
¥询价/250ug
产品说明书
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购买方式
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产品新闻
背景资料
HMG-CoA reductase (HMGR) is a highly regulated enzyme found on the endoplasmic reticulum (ER) membrane. It is bound to the ER membrane by a multi-pass 339 amino acid N-terminal transmembrane domain while the carboxy terminal catalytic region projects into the cytosol.{26861,26862} HMGR is controlled by feedback regulation from sterols and non-sterol metabolites derived from mevalonate.{26862,26863,26860} Binding of cholesterol derived from internalized LDL receptors suppresses HMGR. The enzyme is responsible for catalyzing the rate-limiting step in cholesterol biosynthesis. Mevalonate, which is converted to isopentenyl pyrophosphate, is the building block for cholesterol and non-sterol isoprenoids. The four-electron reduction of HMG-CoA catalyzed by HMGR to form mevalonate is the committed step in the biosynthesis of sterols and isoprenoids.{15309} Potent inhibitors of HMGR, collectively called statins, are effective in lowering mortality due to hypercholesterolemia by lowering serum cholesterol levels.{26864}
产品描述
提供的重组人HMG-乙酰辅酶A还原酶(250ug)产品形式为:50 mM Tris, pH 8.0, containing 300 mM sodium chloride and 20% glycerol.
产品形式
HMG-CoA reductase (HMGR) is a highly regulated enzyme found on the endoplasmic reticulum (ER) membrane. It is bound to the ER membrane by a multi-pass 339 amino acid N-terminal transmembrane domain while the carboxy terminal catalytic region projects into the cytosol.{26861,26862} HMGR is controlled by feedback regulation from sterols and non-sterol metabolites derived from mevalonate.{26862,26863,26860} Binding of cholesterol derived from internalized LDL receptors suppresses HMGR. The enzyme is responsible for catalyzing the rate-limiting step in cholesterol biosynthesis. Mevalonate, which is converted to isopentenyl pyrophosphate, is the building block for cholesterol and non-sterol isoprenoids. The four-electron reduction of HMG-CoA catalyzed by HMGR to form mevalonate is the committed step in the biosynthesis of sterols and isoprenoids.{15309} Potent inhibitors of HMGR, collectively called statins, are effective in lowering mortality due to hypercholesterolemia by lowering serum cholesterol levels.{26864}
保存建议
建议您在收到Cayman Chemical品牌的重组人HMG-乙酰辅酶A还原酶(250ug)产品后置于-80度保存,产品有效期为270天.
其他
Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒,其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒,如:类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等;也提供多种高质量试剂,包括:类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理,艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.
注意
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