Cyclopeptide inhibitor of histone deactylases (HDACs). Inhibits HeLa cell proliferation (IC50=50-100nM) and induces reversible transcriptional activation of p21 (WAF1). Decreases HIF1alpha protein levels and transcriptional activity in human and mouse tumor cell lines. Cell permeable.Solubility:DMSO (~10mg/ml)Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.