Cyclosporin A is an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells (IC50 = 5 nM).{24989,20555,25125} It blocks the transcription of genes involved in T cell activation by interfering with the calcineurin-driven nuclear import of the transcription factor NFAT.{24989,21639,21213} Because of its powerful immunosuppressant activity, cyclosporin A has long been used for the prevention of transplant rejection.{25124}
产品描述
An immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells (IC50 = 5 nM), which interferes with the nuclear import of NFAT, a transcription factor involved in T cell activation; used for the prevention of transplant rejection
产品形式
A white solid
保存建议
建议您在收到Cayman Chemical品牌的Cyclosporin A (100 mg)产品后置于-20度保存,产品有效期为730天.