中文名称

韦利帕里布;?2-[（（2R）-2-甲基-2-吡咯烷基] -1H-苯并咪唑-7-羧酰胺，二盐酸盐

英文名字

Veliparib; 2-[(2R)-2-methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide, dihydrochloride

供应商

开曼生物

产品货号

11505-1

产品报价

￥1/1mg

产品说明书

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产品新闻

背景资料

Poly(ADP-ribose) polymerases (PARPs) have diverse roles in cellular processes, including DNA repair and apoptosis.{22577,20553} ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively).{24824} It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation.{24828,24825} ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively).{24824} It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation.{24828,24825} ABT-888 also acts synergistically with chemotherapies to increase the lethal effects of radiation in cancer cells.{24827,24826}

产品描述

An orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively); enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation

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