中文名称

17（S）-Resolvin D1-d5 | RvD1-d5; 7S，8R，17S-三羟基-4Z，9E，11E，13Z，15E，19Z-21,21'，22,22,22-d5二十二碳六烯酸

英文名字

17(S)-Resolvin D1-d5|RvD1-d5; 7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-21,21',22,22,22-d5 docosahexaenoic acid

供应商

Cayman Chemical

产品货号

11182-50

产品报价

￥已停产

产品说明书

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购买方式

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产品新闻

背景资料

Resolvin D1-d5 (RvD1-d5) contains five deuterium atoms at the 21, 21', 22, 22, and 22 positions. It is intended for use as an internal standard for the quantification of RvD1 (Item No. 10012554) by GC- or LC-mass spectrometry. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310).{13989} In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.{14973} RvD1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.{13989} A 17(R)-epimer of RvD1 can also be generated in aspirin-treated samples.{11433} Both RvD1 and its 17(R) configuration reduce human polymorphonuclear leukocyte (PMNL) transendothelial migration, the earliest event in acute inflammation, with EC50 values of ~30 nM.{15718} RvD1 and its aspirin-triggered form also exhibit a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with a maximal inhibition of ~35% at a 10-100 ng dose.{15718}

产品描述

An internal standard for the quantification of resolvin D1 by GC- or LC-MS

产品形式

A solution in ethanol

保存建议

建议您在收到Cayman Chemical品牌的Resolvin D1-d5 (50 µg)产品后置于-80度保存，产品有效期为365天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

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