- 中文名称
Simvastatin (10 mg)
- 英文名字
- MK 733, Simvastatin, 2,2-dimethyl-1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, butanoic acid
- 供应商
- Cayman
- 产品货号
- 10010344-10
- 产品报价
- ￥448/10 mg
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- Hydroxymethylglutaryl-coenzyme A -HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the statin class of cholesterol-lowering drugs. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule. Simvastatin is marketed under the trade name ZocorTM and is often prescribed in combination with ezetimibe -Zetia) to treat dyslipidemia. This drug combination is known commercially as VytorinTM or InegyTM. After 18 days of treatment with simvastatin in dogs at a dose of 8 mg/kg per day, plasma cholesterol levels were reduced by 33%. Simvastatin also suppresses TNF-induced NF-.kappa.B activation -IC50 ~ 13 uM), which potentiates apoptosis in human myeloid leukemia cells and thus may be useful in treating cancer.
- 产品描述
- A potent, competitive inhibitor of HMG-CoA reductase -Ki = 0.12 nM)
- 产品形式
- 保存建议
- -20
- 其他
- Cayman Chemical
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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