中文名称

Lovastatin (25 mg)

英文名字

Lovastatin, 2-methyl-1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, butanoic acid

供应商

Cayman

产品货号

10010338-25

产品报价

￥1008/25 mg

产品说明书

点击查看

购买方式

产品新闻

背景资料

Hydroxymethylglutaryl-coenzyme A -HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the statin class of cholesterol-lowering drugs. Lovastatin is an HMG-CoA reductase inhibitor that was initially isolated from Aspergillus terreus. Marketed as MevinolinTM, MevacorTM, and under several other trade names, Lovastatin was the first HMG-CoA reductase inhibitor to be used in the treatment of hypercholesterolemia. It is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.6 nM for the open ring, hydroxy acid form of the molecule. During a three week study in dogs, a dose of 8 mg/kg per day resulted in a 29% reduction in plasma cholesterol. Lovastatin also suppresses TNF-induced NF-.kappa.B activation -IC50 ~ 15 uM), which potentiates apoptosis in human myeloid leukemia cells and thus, maybe useful in treating cancer.

产品描述

A potent, competitive inhibitor of HMG-CoA reductase -Ki = 0.6 nM)

产品形式

保存建议

-20

其他

Cayman Chemical

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

分享到：