- 中文名称
PDM 2 (500 mg)
- 英文名字
- PDM 2, 1,3-dichloro-5-[(1E)-2-(4-chlorophenyl)ethenyl]-benzene
- 供应商
- Cayman
- 产品货号
- 10006342-500
- 产品报价
- ￥16170/500 mg
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- The aryl hydrocarbon receptor -AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar. PDM 2 is an analog of resveratrol acting as a potent and selective AhR antagonist, with a Ki of 1.2 nM. PDM 2 is inactive as a ligand for the estrogen receptor even at 100 uM. As AhR knockout mice are insensitive to the carcinogenic effects of classical AhR ligands, PDM 2 is a potential therapeutic for the treatment for dioxin and other aryl hydrocarbon poisonings.
- 产品描述
- The aryl hydrocarbon receptor -AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar.{12907} PDM 2 is an analog of resveratrol acting as a potent and selective AhR antagonist, with a Ki of 1.2 nM.{12475} PDM 2 is inactive as a ligand for the estrogen receptor even at 100 uM. As AhR knockout mice are insensitive to the carcinogenic effects of classical AhR ligands, PDM 2 is a potential therapeutic for the treatment for dioxin and other aryl hydrocarbon poisonings.
- 产品形式
- 保存建议
- -20
- 其他
- Cayman Chemical
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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